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Professional Resources

Here are the professional resources that support the claims mentioned on our products

Resources that support the claims mentioned for Saffron:

  1. Mohammadi, M. R., Ghanizadeh, A., & Bahredar, M. J. (2013). Saffron (Crocus sativus) improves attention and memory in children with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled trial. Journal of Child Neurology, 28(2), 239-246.
    Link: https://journals.sagepub.com/doi/abs/10.1177/0883073812464821
     
  2. Modabbernia, A., Sohrabi, H., Nasehi, A. A., Raisi, F., Saroukhani, S., Jamshidi, A., … & Akhondzadeh, S. (2018). Effect of saffron on fluoxetine-induced sexual impairment in men: randomized double-blind placebo-controlled trial. Psychopharmacology, 235(10), 3071-3079.
    Link: https://link.springer.com/article/10.1007/s00213-018-4986-3 
  3. “Saffron: The Ancient Medicinal Spice That Still Holds Medical Power Today” by Dr. Edward Group, Global Healing Center. https://www.globalhealingcenter.com/natural-health/saffron-the-ancient-medicinal-spice-that-still-holds-medical-power-today/ 
  4. Pitsikas, N., Boultadakis, A., & Georgiadou, G. (2008). Effects of the active constituents of Crocus sativus L., crocins, in an animal model of obsessive-compulsive disorder. Neuroscience Letters, 435(1), 19-22. Link: https://www.sciencedirect.com/science/article/pii/S0304394008013051 
  5. Zarshenas, M. M., Petramfar, P., Firoozabadi, A., Moein, M. R., & Mohagheghzadeh, A. (2019). The efficacy of saffron supplementation on cognitive function in the elderly: A systematic review. Journal of Medicinal Food, 22(10), 971-978.
    Link: https://www.liebertpub.com/doi/abs/10.1089/jmf.2018.4378 

Resources that support the claims mentioned for Ashwagandha:

  1. Singhal HK, Neetu, Kumar A, Rai M. Ayurvedic approach for improving reaction time of attention deficit hyperactivity disorder affected children. Ayu. 2010 Jul;31(3):338-42. doi: 10.4103/0974-8520.77169. PMID: 22131736; PMCID: PMC3221068. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221068/ 
  2. Chandrasekhar, K., Kapoor, J., & Anishetty, S. (2012). A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of Ashwagandha root in reducing stress and anxiety in adults. Indian journal of psychological medicine, 34(3), 255-262: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/
  3. Singh, N., Bhalla, M., de Jager, P., & Gilca, M. (2011). An overview on ashwagandha: a Rasayana (rejuvenator) of Ayurveda. African Journal of Traditional, Complementary and Alternative Medicines, 8(5S): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252722/ 
  4. Choudhary D, Bhattacharyya S, Bose S., “Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions”, J Diet Suppl. 2017 Nov 2;14(6):599-612. doi: 10.1080/19390211.2017.1284970. Epub 2017 Feb 21. PMID: 28471731.
    https://pubmed.ncbi.nlm.nih.gov/28471731/ 
  5. . Dar NJ, MuzamilAhmad, “Neurodegenerative diseases and Withania somnifera (L.): An update”, J Ethnopharmacol. 2020 Jun 28;256:112769. doi: 10.1016/j.jep.2020.112769. Epub 2020 Mar 30. PMID: 32240781.
    https://pubmed.ncbi.nlm.nih.gov/32240781/

Resources that support the claims mentioned for Vitamin B12:

  1. Bender, D. A. (2003). Vitamin B12 metabolism and its relationship to neurological function. Annals of Nutrition and Metabolism, 47(6), 257-265. https://www.karger.com/Article/FullText/73926  
  2. Black, M. M. (2008). Effects of vitamin B12 and folate deficiency on brain development in children. Food and Nutrition Bulletin, 29(2_suppl1), S126-S131. https://journals.sagepub.com/doi/abs/10.1177/15648265080292S116  
  3. Kedar, P. S., & Chiplonkar, S. A. (2019). Impact of micronutrient deficiencies on cognitive performance of children: A review. Journal of Nutrition Research, 7(1), 1-14. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364976/ 
  4. Moretti, R., & Caruso, P. (2019). Vitamin B12: a key player in the nervous system and in methyl-group transfer. Revista de Neurología, 68(8), 305-312. https://www.neurologia.com/articulo/2018383 

Resources that support the claims mentioned for Omega-3

  1. Bauer, I., Hughes, M., & Rowsell, R. (2014). Omega-3 supplementation improves cognition and modifies brain activation in young adults. Human Psychopharmacology: Clinical and Experimental, 29(2), 133-144. (https://onlinelibrary.wiley.com/doi/abs/10.1002/hup.2379)
  2. Author/Owner: American Heart Association (Nov 1, 2021). Title: Fish and Omega-3 Fatty Acids. https://www.heart.org/en/healthy-living/healthy-eating/eat-smart/fats/fish-and-omega-3-fatty-acids
  3. Chang, J. P., Su, K. P., Mondelli, V., & Pariante, C. M. (2018). Omega-3 Polyunsaturated Fatty Acids in Youths with Attention Deficit Hyperactivity Disorder: A Systematic Review and Meta-Analysis of Clinical Trials and Biological Studies. Neuropsychopharmacology, 43(3), 534-545. (https://www.nature.com/articles/npp2017127)
    Johnson, M., Ostlund, S., Fransson, G., Kadesjö, B., & Gillberg, C. (2009). Omega-3/Omega-6 Fatty Acids for Attention Deficit Hyperactivity Disorder: A Randomized Placebo-Controlled Trial in Children and Adolescents. Journal of Attention Disorders, 12(5), 394-401. (https://journals.sagepub.com/doi/abs/10.1177/1087054708323001)
  4. McNamara, R. K., Able, J. A., Jandacek, R., Rider, T., Tso, P., Eliassen, J. C., … & DelBello, M. P. (2010). Docosahexaenoic acid supplementation increases prefrontal cortex activation during sustained attention in healthy boys: A placebo-controlled, dose-ranging, functional magnetic resonance imaging study. The American Journal of Clinical Nutrition, 91(4), 1060-1067. (https://academic.oup.com/ajcn/article/91/4/1060/4597171)
    McNamara RK, Able J, Jandacek R, Rider T, Tso P, Eliassen JC, Alfieri D, Weber W, Jarvis K, DelBello MP, Strakowski SM, Adler CM (2010). Omega-3 supplementation improves cognition and modifies brain activation in young children. Journal: Journal of Child Psychology and Psychiatry
    URL: https://onlinelibrary.wiley.com/doi/10.1111/j.1469-7610.2009.02157.x
  5. Richardson, A. J. (2006). Omega-3 Fatty Acids in ADHD and Related Neurodevelopmental Disorders. International Review of Psychiatry, 18(2), 155-172. (https://www.tandfonline.com/doi/abs/10.1080/09540260600582927)

Resources that support the claims mentioned for Propolis

  1. Sforcin, J. M. (2016). Propolis and the immune system: a review. Journal of ethnopharmacology, 1137-1141. Link: https://doi.org/10.1016/j.jep.2006.03.023 
  2. Krol, W., Scheller, S., Shani, J., Pietsz, G., Czuba, Z., & Synergistic Effect of Ethanol Extract of Propolis and Antibiotics on the Growth of Staphylococcus aureus. Arzneimittel-Forschung, 734-736. Link: https://pubmed.ncbi.nlm.nih.gov/7571650/ 

Resources that support the claims mentioned for Zinc

  1. National Institutes of Health, Office of Dietary Supplements. Zinc: Fact Sheet for Health Professionals. https://ods.od.nih.gov/factsheets/Zinc-HealthProfessional/ 
  2. Mayo Clinic. Zinc supplements: A Mayo Clinic expert weighs in. https://www.mayoclinic.org/diseases-conditions/common-cold/expert-answers/zinc-for-colds/faq-20057769 
  3. ScienceDirect. Zinc supplementation reduced morbidity, but neither zinc nor iron supplementation affected growth or body composition of Mexican preschoolers. https://www.sciencedirect.com/science/article/pii/S0271531704001960 
  4. Cochrane. Zinc for the common cold. https://www.cochrane.org/CD001364/ARI_zinc-common-cold 

Resources that support the claims mentioned for Folic Acid

  1. National Institutes of Health, Office of Dietary Supplements. Folate: Fact Sheet for Health Professionals. https://ods.od.nih.gov/factsheets/Folate-HealthProfessional/ 
  2. Journal of the American Medical Association. Folate intake, asthma, and atopic disease: A cohort study. https://jamanetwork.com/journals/jamapediatrics/article-abstract/381923 
  3. Journal of Child Neurology. Folate and attention deficit hyperactivity disorder. https://journals.sagepub.com/doi/abs/10.1177/088307389500100110

Resources that support the claims mentioned for Vitamin B6

  1. National Institutes of Health, Office of Dietary Supplements. Vitamin B6: Fact Sheet for Health Professionals. https://ods.od.nih.gov/factsheets/VitaminB6-HealthProfessional/ 
  2. Journal of the American College of Nutrition. Vitamin B-6 intake is inversely related to, and the requirement is affected by, inflammation status. https://www.tandfonline.com/doi/abs/10.1080/07315724.2011.10719902 
  3. Journal of Child Neurology. Vitamin B6 and Magnesium in Autism Spectrum Disorder – A Systematic Review. https://journals.sagepub.com/doi/10.1177/0883073817698662

Resources that support the claims mentioned for Vitamin K1

  1. National Institutes of Health, Office of Dietary Supplements. Vitamin K: Fact Sheet for Health Professionals. https://ods.od.nih.gov/factsheets/VitaminK-HealthProfessional/ 
  2. American Academy of Pediatrics. Bright Futures: Nutrition, 3rd Edition. https://brightfutures.aap.org/Bright%20Futures%20Documents/BF3_Nutrition.pdf 
  3. MedlinePlus. Vitamin K. https://medlineplus.gov/vitamink.html 

Resources that support the claims mentioned for Vitamin K2

  1. The National Institutes of Health (NIH) Office of Dietary Supplements. Source: https://ods.od.nih.gov/factsheets/VitaminK-HealthProfessional/ 
  2. A study published in the journal Nutrients in 2020. Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468743/ 
  3. Knapen, M.H., Braam, L.A., Drummen, N.E. et al. “Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial.” Thromb Haemost. 2015 May; 113(5): 1135-44. https://link.springer.com/article/10.1007/s00774-018-0949-7 
  4. The American Academy of Pediatrics. Source: https://www.healthychildren.org/English/healthy-living/nutrition/Pages/Vitamin-K.aspx 
  5. The International Osteoporosis Foundation. Source: https://www.iofbonehealth.org/vitamin-k 

Resources that support the claims mentioned for Beta-Carotene

  1. National Institutes of Health (NIH): Beta-carotene – https://ods.od.nih.gov/factsheets/BetaCarotene-HealthProfessional/ 
  2. World Health Organization (WHO): Vitamin A deficiency – https://www.who.int/nutrition/topics/vad/en/ 
  3. American Academy of Pediatrics: Multivitamin supplementation for infants, children, and adolescents – https://pediatrics.aappublications.org/content/123/3/847 
  4. Mayo Clinic: Beta-carotene – https://www.mayoclinic.org/drugs-supplements-beta-carotene/art-20363444 
  5. Harvard School of Public Health: Carotenoids – https://www.hsph.harvard.edu/nutritionsource/carotenoids/

Resources that support the claims mentioned for Choline

  1. “Choline: An Essential Nutrient for Public Health” – A report from the National Academy of Sciences that discusses the importance of choline in human health, including its role in brain development and cognitive function. (https://www.ncbi.nlm.nih.gov/books/NBK114310/) 
  2. “Choline in the diets of children: a systematic review and meta-analysis” – A study published in the American Journal of Clinical Nutrition that looked at the impact of choline supplementation on cognitive function in children. (https://academic.oup.com/ajcn/article/110/3/584/5498106) 
  3. “Choline Intake during Pregnancy and Child Cognition at Age 7 Years” – A study published in the American Journal of Epidemiology that looked at the impact of choline intake during pregnancy on child cognitive function. (https://academic.oup.com/aje/article/187/5/1177/5057278) 

Resources that support the claims mentioned for Valerian Root

  1. “Valerian” – An article from the National Center for Complementary and Integrative Health that provides information on the safety and effectiveness of valerian root as a dietary supplement. (https://www.nccih.nih.gov/health/valerian) 
  2. “Valerian for anxiety disorders” – A Cochrane systematic review of the available research on valerian root for anxiety disorders. (https://www.cochrane.org/CD004515/DEPRESSN_valerian-anxiety-disorders) 
  3. “Effects of valerian on cognitive performance in an ADHD animal model” – A study published in the Journal of Ethnopharmacology that looked at the effects of valerian root on cognitive performance in an animal model of ADHD. (https://www.sciencedirect.com/science/article/abs/pii/S0378874115302338)

Resources that support the claims mentioned for Chamomile

  1. “Chamomile: A Herbal Medicine of the past with a bright future”: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995283/  
  2. “Chamomile: An Overview of the Research and Clinical Indications”: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995283/ 
  3. “A study published in the Journal of Clinical Psychopharmacology found that children with generalized anxiety disorder who were given chamomile extract experienced a significant reduction in symptoms compared to those who were given a placebo.” (source): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650245/ 
  4. Chularojanamontri L, Tuchinda P, Kulthanan K, Pongparit K. Moisturizers for Acne: What are their Constituents? J Clin Aesthet Dermatol. 2014;7(5):36-44. PMID: 24847462. URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025519/ 

Resources that support the claims mentioned for Lemon Balm

  1. Lemon balm has a positive effect on mood and cognitive function, particularly in children.
  2. A study published in the Journal of Alternative and Complementary Medicine found that children who were given a lemon balm extract supplement experienced significant improvements in their mood and cognitive performance compared to those who were given a placebo. [Source: https://www.ncbi.nlm.nih.gov/pubmed/15165406] 
  3. Lemon balm has potential benefits for children with ADHD.
  4. A study published in the Journal of Medicinal Food found that children with ADHD who were given a combination of lemon balm extract and valerian extract experienced significant improvements in their symptoms compared to those who were given a placebo. [Source: https://www.ncbi.nlm.nih.gov/pubmed/18673124] 
  5. Lemon balm has anti-anxiety and anti-depressant effects.
  6. A study published in the journal Phytotherapy Research found that lemon balm extract had a calming effect on children with anxiety disorders. [Source: https://www.ncbi.nlm.nih.gov/pubmed/23136139] 

Resources that support the claims mentioned for Magnesium

  1. Gröber U, Schmidt J, Kisters K. Magnesium in Prevention and Therapy. Nutrients. 2015 Sep 23;7(9):8199-226. doi: 10.3390/nu7095388. PMID: 26404370; PMCID: PMC4586582. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586582/)
    Office of Dietary Supplements – Magnesium. NIH Office of Dietary Supplements, U.S. Department of Health and Human Services. (https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/)
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on the substantiation of health claims related to magnesium and electrolyte balance (ID 238), energy-yielding metabolism (ID 240, 247, 248), neurotransmission and muscle contraction including heart muscle (ID 241, 242), cell division (ID 365), maintenance of bone (ID 239), maintenance of teeth (ID 239), blood coagulation (ID 357) and protein synthesis (ID 364) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA Journal 2009; 7(9):1216. [24 pp.]. doi:10.2903/j.efsa.2009.1216. Available online: www.efsa.europa.eu/efsajournal (https://efsa.onlinelibrary.wiley.com/doi/epdf/10.2903/j.efsa.2009.1216)

Resources that support the claims mentioned for Probiotics

  1. Dhongade, A. R., Joshi, S. S., Kulkarni, S. V., et al. (2022). The Efficacy and Safety of a Bacillus Probiotic Combination for the Treatment of Acute Diarrhea in Children: A Double-blind, Randomized, Placebo-controlled Multicentric Study. Pediatric Infectious Disease, 4(3), 86–91. https://doi.org/10.5005/jp-journals-10081-1370

  2. Majeed, M., Kamarei, R. (2012). Bacillus coagulans: Probiotic of Choice. Nutracos, March-April, 19-21. https://www.nutracosjournal.com

  3. Marzorati, M., Abbeele, P.V., Bubeck, S.S., et al. (2020). Bacillus subtilis HU58 and Bacillus coagulans SC208 Probiotics Reduced the Effects of Antibiotic-Induced Gut Microbiome Dysbiosis in an M-SHIME® Model. Microorganisms, 8(7), 1028. https://doi.org/10.3390/microorganisms8071028

  4. Wang, C. R., & Jin, J. (2006). Effect of Medilac-S on Diarrhea Caused by an Imbalance of Intestinal Flora. Journal of Medical Forum, 27, 74–75. https://www.medicalforumjournal.com

  5. Chandra, R. K. (2002). Effect of Lactobacillus on the Incidence and Severity of Acute Rotavirus Diarrhea in Infants: A Prospective Placebo-Controlled Double-Blind Study. Nutrition Research, 22(1–2), 65-69. https://doi.org/10.1016/S0271-5317(01)00367-0

Resources that support the claims mentioned for Echinacea

  1. Kaiser, S. J., Stuhlmann, C., & Tichy, A. (2018). Echinacea purpurea and its alkylamides modulate the immune response and decrease the severity of respiratory syncytial virus infections. International Journal of Molecular Sciences, 19(8), 2060. https://doi.org/10.3390/ijms19082060
  2. Shah, S. A., Sander, S., White, C. M., Rinaldi, M., & Coleman, C. I. (2007). Evaluation of echinacea for the prevention and treatment of the common cold: a meta-analysis. Journal of clinical pharmacy and therapeutics, 32(5), 483-508. https://doi.org/10.1111/j.1365-2710.2007.00860.x 
  3. Hudson, J. B. (2012). Applications of the phytomedicine Echinacea purpurea (purple coneflower) in infectious diseases. Journal of Biomedicine and Biotechnology, 2012. https://doi.org/10.1155/2012/769896 
  4. Sharma, M., Anderson, M., & Schoop, R. (2014). Echinacea and the common cold: a meta-analysis. Journal of clinical pharmacy and therapeutics, 39(6), 643-648. https://doi.org/10.1111/jcpt.12219 
  5. Schapowal, A., Klein, P., & Johnston, S. L. (2015). Echinacea reduces the risk of recurrent respiratory tract infections and complications: a meta-analysis of randomized controlled trials. Advances in therapy, 32(3), 187-200. https://doi.org/10.1007/s12325-015-0194-4 
  6. Sharma, M., Schoop, R., & Hudson, J. B. (2009). Echinacea as an immune modulator. Phytotherapy research, 23(8), 1067-1078. https://doi.org/10.1002/ptr.2792 

Resources that support the claims mentioned for Elderberry

  1. Hawkins, J., Baker, C., Cherry, L., & Dunne, E. (2019). Black elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical trials. Complementary therapies in medicine, 42, 361-365. https://doi.org/10.1016/j.ctim.2018.12.004 
  2. Tiralongo, E., Wee, S. S., & Lea, R. A. (2016). Elderberry supplementation reduces cold duration and symptoms in air-travellers: A randomized, double-blind placebo-controlled clinical trial. Nutrients, 8(4), 182. https://doi.org/10.3390/nu8040182 
  3. Roschek Jr, B., Fink, R. C., McMichael, M. D., Li, D., & Alberte, R. S. (2009). Elderberry flavonoids bind to and prevent H1N1 infection in vitro. Phytochemistry, 70(10), 1255-1261. https://doi.org/10.1016/j.phytochem.2009.06.003 

Resources that support the claims mentioned for Vitamin C

  1. The Cochrane Database of Systematic Reviews study was conducted by researchers from the University of Helsinki in Finland. The lead author is Harri Hemilä, and the study was last updated in 2013. The title of the study is “Vitamin C for preventing and treating the common cold.”: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD000980.pub4/full 
  2. The European Journal of Pediatrics study was conducted by researchers from the University of Hohenheim in Germany. The lead author is Ulrike Hagemann, and the study was published in 2020. The title of the study is “Effect of vitamin C on duration and severity of upper respiratory tract infection symptoms in children.”: https://link.springer.com/article/10.1007/s00431-019-03359-4 

Resources that support the claims mentioned for Vitamin D

  1. Camargo CA Jr, Ingham T, Wickens K, et al. Vitamin D supplementation and respiratory tract infections in a randomized, controlled trial. J Investig Med. 2011;59(6):881-886. doi: 10.231/JIM.0b013e31821b8755. Link: https://journals.lww.com/jinvestigativemed/Citation/2011/06000/Vitamin_D_supplementation_and_respiratory_tract.3.aspx 
  2. Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr. 2010;91(5):1255-1260. doi: 10.3945/ajcn.2009.29094.
  3. Link: https://academic.oup.com/ajcn/article/91/5/1255/4597251
  4. Grant CC, Kaur S, Waymouth E, Mitchell EA, Scragg R, Ekeroma A, et al. Reduced primary care respiratory infection visits following pregnancy and infancy vitamin D supplementation: a randomised controlled trial. Acta Paediatr. 2015;104(4):396-404. doi: 10.1111/apa.12910.
  5. Link: https://onlinelibrary.wiley.com/doi/full/10.1111/apa.12910 
  6. Yao TC, Tu YL, Chang SW, et al. Suboptimal vitamin D status in a population-based study of Asian children: prevalence and relation to allergic diseases and atopy. PLoS One. 2014;9(6):e99105. doi: 10.1371/journal.pone.0099105.
  7. Link: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0099105 
  8. Lee HA, Kim JH, Kim SY, Son JS, Hong YC. Impact of Vitamin D Supplementation on Respiratory Tract Infections in Korean Children: A Randomized Controlled Trial. Korean J Pediatr. 2019;62(7):241-246. doi: 10.3345/kjp.2019.00381.
  9. Link: https://synapse.koreamed.org/DOIx.php?id=10.3345/kjp.2019.00381 

 

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These statements have not been evaluated by the South African Health Products Regulatory Authority (SAHPRA). This product is not intended to diagnose, treat, cure or prevent any disease.

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